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Talk with a doctor about potential side effects or interactions with medications or supplements you currently take. Research from 2017 shows minimal to no side effects from using MSM supplements. If you’d like to learn more about weight loss enrol in our free six week online course The Science of Weight Loss – Dispelling Diet Myths, here. Garcinia Cambogia is a tropical fruit that contains a large amount of Hydroxycitric Acid , claimed to aid weight loss.

For the first eight weeks, the group taking caffeine supplements experienced side-effects of insomnia, tremor and dizziness. Caffeine is claimed to increase your metabolic rate and therefore speed up weight loss. Research studies in volunteers of a healthy weight found an increase in metabolic rate, but it depended on the dose. The more caffeine supplements consumed, the more the metabolic rate went up. Some research in animals suggests MSM supplements can help with obesity-related insulin resistance and high blood sugar, including an October 2016 ​Metabolism​ study done in mice. It’s impossible to say whether these results would be the same in humans, though.

There is currently no evidence to suggest a direct link between MSM supplementation and weight gain at the time of writing. Many supplements have minimal side effects that are often harmless for most individuals, and while it appears MSM is safe for most people, not everyone will be free of the potential side effects. Young Living products are not intended to diagnose, treat, cure, or prevent any disease.

With the reduction in cytokines and vasodilating agents, flux and recruitment of immune cells to sites of local inflammation are inhibited. In rats, between 59% and 79% of MSM is excreted the same day as administration in urine, either unchanged or as another S-containing metabolite . Urine is the most common form of excretion as MSM has been detected in urine of rats , rabbits , bobcats , cheetahs , dogs , monkeys , and humans . Additionally, excretion of MSM can be contained in feces or several other biofluids including cow’s milk , red deer tail gland secretion , and human saliva . So far, studies have shown minimal side effects when MSM is taken orally in a dosage of 3 grams daily for six months, but some people may experience mild gastrointestinal side effects such as discomfort or diarrhea. There isn’t enough information about MSM’s safety when you apply it to the skin.

MSM is commonly used as an anti-inflammatory and reliever of joint pain. If an individual was to find some relief from joint pain through supplementing with MSM, they may find physical activity and exercise easier, which may draw a link between increased activity and weight loss. Morton J.I., Siegel B.V. Effects of oral dimethyl sulfoxide and dimethyl sulfone on murine autoimmune lymphoproliferative disease 1. Kalman D.S., Feldman S., Samson A., Krieger D.R. A randomized double blind placebo controlled evaluation of msm for exercise induced discomfort/pain. Melcher D.A., Lee S.-R., Peel S.A., Paquette M.R., Bloomer R.J. Effects of methylsulfonylmethane supplementation on oxidative stress, muscle soreness, and performance variables following eccentric exercise.

In some parts of the world, the soil may not contain sufficient amounts of sulfur, which can cause an inadequate intake. It is part of a liquid solution that is inserted into the bladder. Rosacea is a skin condition that looks like adult acne but is very different. It causes red, swollen areas on the face, red bumps, and an enlargement of the nose.

The broad effects of IL-6 have been implicated in the maintenance of chronic inflammation . MSM has been shown to reduce IL-6 in vitro, which may mitigate these chronic deleterious effects . In macrophage-like cells, pre-treatment with sza plastic surgery MSM in vitro was found to decrease accumulation of the redox sensitive p53 transcription factor . The antioxidative function of p53 upregulates scavenging enzymes like Sestrin, glutathione peroxidase and aldehyde dehydrogenase .

Nakhostin-Roohi B., Niknam Z., Vaezi N., Mohammadi S., Bohlooli S. Effect of single dose administration of methylsulfonylmethane on oxidative stress following acute exhaustive exercise. Touchberry C.D., Von Schulze A., Amat-Fernandez C., Lee H., Chow Y., Wetmore L.A. Methylsulfonylmethane treatment enhances C2C12 wound closure and protects cells from oxidative stress. Caron J.M., Caron J.M. Methyl sulfone blocked multiple hypoxia-and non-hypoxia-induced metastatic targets in breast cancer cells and melanoma cells. Much anecdotal evidence from web forums and videos exists regarding chronic MSM use and increased sensitivity to alcohol. As mentioned previously, MSM readily crosses the blood brain barrier and becomes evenly distributed throughout the brain ; however, studies have not focused on the metabolic effects on the different neural pathways. Further studies are needed to assess the safety of MSM use with recreational alcohol use.