Effects of Naltrexone on Smoking Cessation Outcomes and Weight Gain in Nicotine-Dependent Men and Women PMC

The results of some tests may be affected by this medicine. Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during therapy.

Krishnan-Sarin S, Rosen MI, O’Malley SS. Naloxone challenge in smokers. Preliminary evidence of an opioid component in nicotine dependence. Differences in delta- and mu-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjects. The influence of weight-related variables on smoking cessation.

With either drug, weight loss can result in low blood sugar. Before taking weight-loss meds, talk to your doctor about all of the medical conditions you have, and all of the medications you take, so your doctor can determine if weight-loss medications are safe for you. The Contrave dosage is slowly increased, from one tablet in the morning, over a period of four weeks to its maintenance dosage of two tablets twice daily. Contrave should be taken in the morning and evening, but not with a high-fat meal.

It’s quite early on for you, so it could just be your brain trying to compensate in some way. So far as I know, the treatment dose of Naltrexone for weight loss is higher than what it is for TSM. I’m not sure why, but that’s what I understand anyway. I think when combined with Wellbutrin it is a weight loss drug. I took 200 mg wellbutrin IR and 3 mg of low dose Naltrexone. The Naltrexone was prescribed to me for my thyroid, and the Wellbutrin for anxiety.

Participants and study staff were blinded to treatment assignment. The first 2 visits took place during the 2 weeks before the quit date, the next 4 visits were scheduled once weekly, and the last 4 visits were tapered to every other week biking or walking for weight loss and concluded 12 weeks after quit date. Follow-ups were conducted by telephone at 26 and 52 weeks after the quit date, and those who reported smoking abstinence were asked to attend an in-person visit to provide biochemical confirmation.

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